Psychopharmacology & Therapeutics
This focus area investigates how pharmacological and biological interventions influence mental health, cognition, behaviour, and clinical outcomes.
Our research investigates the efficacy, safety, and mechanisms of both established and emerging therapeutic approaches, with a particular interest in treatments relevant to depression, cognitive impairment, metabolic health, and other neuropsychiatric conditions.
RELEVANT PUBLICATIONS
Are the current safety measures for the treatment of depression with esketamine sufficient? Valentino K, Teopiz K, Dri C, Swainson J, …. McIntyre RS. Expert Opinion on Drug Safety. https://doi.org/10.1080/14740338.2026.2627184
The effect of glutamatergic modulators on sleep behavior and architecture in depressive disorders: A systematic review. Valentino K, Ballum H, Cheung W, Dri C, …. McIntyre RS. Journal of Psychiatric Research. https://doi.org/10.1016/j.jpsychires.2026.02.011
Efficacy of Xanomeline and Xanomeline-Trospium in the Treatment of Cognitive Impairment: A Systematic Review of Preclinical and Clinical Trials. Valentino K, Shen B, Waisman B … McIntyre RS. European Neuropsychopharmacology.
Seltorexant for Major Depressive Disorder. Valentino K, Teopiz K, Wong S … McIntyre RS (2025). Expert Opinion on Emerging Drugs. https://doi.org/10.1080/14728214.2025.2452514
The Effect of Glucagon-Like Peptide-1 Receptor Agonists on Measures of Suicidality: A Systematic Review. Valentino K, Teopiz K, Cheung W … McIntyre RS (2025). Journal of Psychiatric Research. https://doi.org/10.1016/j.jpsychires.2025.02.008
Anatomical, Behavioral, and Cognitive Teratogenicity Associated with Valproic Acid: A Systematic Review. Valentino K, Teopiz K, Kwan A … McIntyre RS. CNS Spectrums. https://doi.org/10.1017/s1092852924002311
Efficacy of Estrogenic Mechanisms in Pathological Aggression: A Systematic Review of Preclinical and Clinical Trials.
Oană B, Kanbar A, Clark L, Valentino K ... Journal of Psychiatry and Brain Science. https://doi.org/10.20900/jpbs.20260007